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Naoki Nagata Selected Research

TAC 101

6/2009Chemopreventive effect of 4-[3,5-Bis(trimethylsilyl) benzamido] benzoic acid (TAC-101) on MNU-induced colon carcinogenesis in a rat model.
3/20074- [3,5-bis(trimethylsilyl)benzamido] benzoic acid (TAC-101) induced fas expression and activated caspase-3 and -8 in a DLD-1 colon cancer cell line.
1/20054-[3,5-Bis(trimethylsilyl)benzamido] benzoic acid (TAC-101) induces apoptosis in colon cancer partially through the induction of Fas expression.
1/20044-[3,5-Bis(trimethylsilyl)benzamido] benzoic acid inhibits angiogenesis in colon cancer through reduced expression of vascular endothelial growth factor.

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Naoki Nagata Research Topics

Disease

30Colorectal Neoplasms (Colorectal Cancer)
12/2022 - 04/2002
20Neoplasms (Cancer)
11/2020 - 04/2002
11Stomach Neoplasms (Stomach Cancer)
01/2018 - 04/2004
7Colonic Neoplasms (Colon Cancer)
01/2021 - 01/2004
5Neoplasm Metastasis (Metastasis)
12/2011 - 09/2002
4Stomatitis
01/2018 - 01/2014
3Peripheral Nervous System Diseases (PNS Diseases)
04/2021 - 12/2016
3Diarrhea
01/2016 - 01/2006
3Adenocarcinoma
12/2011 - 04/2002
3Lymphatic Metastasis
04/2004 - 09/2002
2Type 1 Diabetes Mellitus (Autoimmune Diabetes)
03/2010 - 10/2005
2Rectal Neoplasms (Rectal Cancer)
03/2009 - 01/2006
2Carcinoma (Carcinomatosis)
11/2005 - 01/2003
1Bone Neoplasms (Bone Cancer)
01/2021
1Prostatic Neoplasms (Prostate Cancer)
01/2021
1Liver Neoplasms (Liver Cancer)
01/2021
1Neutropenia
12/2020
1Sarcoma (Soft Tissue Sarcoma)
12/2016
1Acneiform Eruptions
12/2016
1Anorexia
01/2016
1Pain (Aches)
12/2015
1Mucositis
07/2015
1Schizophrenia (Dementia Praecox)
12/2011
1Pneumonia (Pneumonitis)
11/2009
1Fatigue
11/2009
1Esophagitis
11/2009
1Hyponatremia
11/2009
1Thrombocytopenia (Thrombopenia)
11/2009
1Carcinogenesis
06/2009
1Anaphylaxis (Anaphylactic Shock)
03/2009

Drug/Important Bio-Agent (IBA)

12Oxaliplatin (Eloxatin)FDA LinkGeneric
01/2021 - 12/2011
9Fluorouracil (Carac)FDA LinkGeneric
01/2018 - 11/2005
8Paclitaxel (Taxol)FDA LinkGeneric
05/2013 - 04/2004
6Leucovorin (Folinic Acid)FDA Link
02/2017 - 12/2011
5Panitumumab (Vectibix)FDA Link
12/2022 - 01/2017
5Cetuximab (Erbitux)FDA Link
11/2019 - 10/2015
5XELOXIBA
12/2016 - 07/2015
5Cisplatin (Platino)FDA LinkGeneric
05/2013 - 11/2005
4Capecitabine (Xeloda)FDA Link
01/2018 - 06/2016
4Benzoic Acid (Potassium Benzoate)FDA Link
06/2009 - 01/2004
4TAC 101IBA
06/2009 - 01/2004
4Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
09/2004 - 07/2002
3Bevacizumab (Avastin)FDA Link
12/2020 - 01/2016
3Irinotecan (Camptosar)FDA LinkGeneric
04/2019 - 12/2013
3pyrimidineIBA
07/2015 - 11/2005
3Uridine Diphosphate (UDP)IBA
04/2011 - 04/2002
3Peptides (Polypeptides)IBA
04/2011 - 04/2002
3Interleukin-12 (IL 12)IBA
03/2008 - 09/2004
3Proteins (Proteins, Gene)FDA Link
01/2008 - 04/2002
3Indicators and Reagents (Reagents)IBA
09/2002 - 04/2002
2ThrombomodulinIBA
04/2021 - 11/2020
2trifluridine tipiracil drug combinationIBA
12/2020 - 01/2016
2hange-shashintoIBA
01/2018 - 07/2015
2TransferasesIBA
04/2011 - 04/2002
2Dihydrouracil Dehydrogenase (NADP) (Dihydropyrimidine Dehydrogenase)IBA
09/2006 - 11/2005
2EnzymesIBA
11/2005 - 06/2003
2GalactosamineIBA
01/2003 - 04/2002
2Polypeptide N-acetylgalactosaminyltransferaseIBA
01/2003 - 04/2002
2Angiogenesis Inducing Agents (Angiogenesis Factor)IBA
09/2002 - 07/2002
1Cell-Free Nucleic AcidsIBA
12/2022
1ART123IBA
11/2020
1ErbB Receptors (EGF Receptor)IBA
11/2019
1lactate dehydrogenase 1 (LDH1)IBA
04/2019
1lactate dehydrogenase 4IBA
04/2019
1Carcinoembryonic AntigenIBA
04/2019
1IsoenzymesIBA
04/2019
1Circulating Tumor DNAIBA
02/2019
1Aluminum Oxide (Sapphire)IBA
01/2017
1Alanine Transaminase (SGPT)IBA
12/2016
1thiamine triphosphorate (TTP)IBA
07/2016
1Hemoglobins (Hemoglobin)IBA
01/2016
1regorafenibIBA
01/2016
1SteroidsIBA
12/2015
1Dexamethasone (Maxidex)FDA LinkGeneric
12/2015
1Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA
07/2015
1Dinoprostone (PGE2)FDA Link
07/2015
1Phosphoric Monoester Hydrolases (Phosphatases)IBA
01/2014
1gosha-jinki-ganIBA
12/2013
1TegafurIBA
12/2011
1UracilIBA
12/2011
1Dacarbazine (DIC)FDA LinkGeneric
11/2009
1Methylnitrosourea (N-Methyl-N-nitrosourea)IBA
06/2009

Therapy/Procedure

16Drug Therapy (Chemotherapy)
01/2021 - 04/2004
11Therapeutics
01/2021 - 03/2007
3Combination Drug Therapy (Combination Chemotherapy)
01/2016 - 09/2008
2Adjuvant Chemotherapy
01/2021 - 01/2006
2Kampo Medicine (Kampo)
12/2015 - 07/2015
2Transplantation
03/2010 - 10/2005
2Laparotomy
01/2006 - 01/2005
2Gastrectomy
12/2005 - 04/2004
1Drug Tapering
12/2020
1Salvage Therapy
01/2016
1Traditional Medicine (Folk Remedies)
12/2015
1Neoadjuvant Therapy
05/2013
1TP protocol
05/2013
1Colectomy
12/2011
1Hepatectomy
12/2011
1Aftercare (After-Treatment)
12/2011
1Islets of Langerhans Transplantation
03/2010
1Rectal Administration
06/2009